Dietary spermidine for lowering high blood pressure
نویسندگان
چکیده
Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy. In salt-sensitive rats, spermidine supplementation also delays the development of hypertensive heart disease, coinciding with reduced arterial blood pressure. The high blood pressure-lowering effect likely results from improved global arginine bioavailability and protection from hypertension-associated renal damage. The polyamine spermidine is naturally present in human diets, though to a varying amount depending on food type and preparation. In humans, high dietary spermidine intake correlates with reduced blood pressure and decreased risk of cardiovascular disease and related death. Altogether, spermidine represents a cardio- and vascular-protective autophagy inducer that can be readily integrated in common diets.
منابع مشابه
Dietary intake of calcium, magnesium and potassium in relation to blood pressure: Tehran Lipid and Glucose Study
Introduction: In spite of many studies about the association of diet with blood pressure, yet the relationship between micronutrients and blood pressure remains obscure. This study aimed at evaluating the dietary intake of calcium, magnesium and potassium in relation to blood pressure. Materials and Methods: Trained interviewers collected dietary data on 1470 participants of Tehran Lipid and Gl...
متن کاملDietary Approaches to Stop Hypertension (DASH) Eating Plan: Beyond the Hypertension
Background and Objectives: Dietary Approaches to Stop Hypertension (DASH) eating pattern, a diet rich in fruits, vegetables, whole grains and low-fat dairy with a reduced content of sodium, saturated fat, and total fat is introduced as an appropriate diet for hypertension. This eating pattern was basically designed to normalize blood pressure in patients with hypertension, and a large body of d...
متن کاملA Systematic Review on the Relationship of Dietary Habits and Blood Pressure in the Pediatric Age Group
Background Tracking of blood pressure from early life to adulthood and the increasing prevalence of elevated blood pressure in the pediatric age group are considered as important health issues. Rapid lifestyle change and dietary habits are considered as important determinants of this problem. This study aimed to systematically review the studies on the association of dietary habits and blood pr...
متن کاملAssessment of Dietary Adherence in Hypertensive Patients Referred to Shahid Sayyad Shirazi Teaching Hospital in Gorgan
Background: Hypertension is a risk factor for many diseases. Nutritional methods are considered as major tools in lifestyle modification for lowering blood pressure. The present study was conducted to determine the level of dietary adherence in hypertensive patients. Methods: This descriptive-analytical study was performed in 2015, on hypertensive patients who were referred to Heart Clinic o...
متن کاملEffect of Drug and Diet Treatment of Mild Hypertension on Diastolic Blood Pressure
The Trial of Antihypertensive Interventions and Management is a multicenter randomized trial designed to examine the diastolic blood pressure response of various combinations of pharmacological and dietary interventions in the treatment of mild hypertension (diastolic blood pressure 90-100 mm Hg). Eight hundred and seventy-eight participants at 110-160% of ideal weight were randomly allocated t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2017